Peyronie’s Disease

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Peyronie’s Disease Treatment

Peyronie’s Disease Doctor in Columbus, Ohio

Most penises are NOT perfectly straight – in fact, it’s quite common for a penis to curve slightly to the left, right, up or down while erect. However, a new curve or a more significant curve that makes sex difficult or painful is a cause for concern.

Peyronie’s disease occurs when scar tissue, called a “plaque,” develops under the skin of the penis and pulls on the surrounding tissue, causing the penis to bend or curve, usually most noticeable when erect. Peyronie’s disease effects the shape and size of the penis, but does not impact urination or ejaculation. The most significant impact stems from difficulty or discomfort for the man or his partner during sex.


Peyronie’s Disease CAN be treated. Though surgery is the gold standard, there are also non-surgical options available.

What are the risk factors for Peyronie’s Disease?

1. Age

Peyronie’s disease is more like to happen as you get older, typically between the ages of 40 and 70, although it can happen at any age.

2. Genetics

If you have a close relative with the disease, such as your father or bother, you are at a higher risk.

3. Prostate cancer

Men who have had surgery for prostate cancer are at an increased risk for developing Peyronie’s Disease.


What are the Treatment options for Peyronie’s Disease?

When a patient first notices a plaque or curvature, it is common for the symptoms to change, or “evolve,” during the active phase.  Rarely a curvature will self-correct, and resolve or decrease.  Most often, following a period of months, the curve “stabilizes” and stops changing.  This is the time when treatment options can be considered.

1. Surgical options for treatment of Peyronie's disease

Surgery remains the gold standard therapy for Peyronie’s disease, as there is no oral medication that has been scientifically proven to improve the plaque.  Options are plaque excision and grafting, penile plication surgery, and placement of a penile prosthesis.  In patients with both Peyronie’s Disease and erectile dysfunction, a penile prosthesis is an excellent option to cure both problems.

2. Non-surgical options for treatment of Peyronie’s Disease

The first FDA-approved non-surgical option for Peyronie’s Disease is called Xiaflex, which is a series of injections administered in the office.  The medication is indicated for curvature of at least 30 degrees, and consists of a series of 4 cycles of 2 injections per cycle.  The goal of Xiaflex is to create small tears in the plaque, softening it and decreasing the curvature.  As with any treatment option, you should discuss the side effects and expected outcomes with your urologist.

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